Rostral ventrolateral medulla C1 neurons and cardiovascular regulation.
作者： Christopher J. Madden , Alan F. Sved
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摘要: 1. The rostral ventrolateral medulla (RVLM) is essential for the normal control of arterial pressure. This region brainstem heterogeneous, and contains spinally projecting neurons that contain phenylethanolamine-N-methyltransferase (C1 neurons) non-C1 neurons. 2. availability a toxin, dopamine-beta-hydroxylase antibody conjugated to saporin, can selectively destroy C1 within RVLM allows study cardiovascular regulation in rats following depletion neuronal population. 3. are not maintenance resting blood pressure anesthetized rats, but do contribute many responses mediated through RVLM. 4. depressor response elicited by clonidine injected into dependent upon 5. Studies with selective toxin-induced destruction demonstrate importantly regulation.
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