Morphometric analysis of the suprachiasmatic and paraventricular nuclei in the human brain: sex differences and age-dependent changes
作者： D F Swaab , M A Hofman , E Goudsmit , E Fliers
DOI:
关键词:
摘要: The size, shape and cellular morphology of the suprachiasmatic (SCN) paraventricular nuclei (PVN) in human hypothalamus were examined relation to sex age. In both nuclear regions following parameters determined: length rostrocaudal axis, maximum cross sectional area, volume, numerical cell density, total number cells diameter nuclei. No sexual difference was observed any these parameters, either SCN or PVN, with exception a dimorphism SCN. contrast absolute measurements, differences found internal structural organisation hypothalamic using multivariate regression analysis. Of measured only volume females showed continuous decrease ageing, whereas changes other variables not consistent. Regression analysis revealed that this is mainly caused by loss rather than reduction size. Finally, comparison volumetric measurements PVN those rat reduced size relative Possible consequences phenomenon for functional significance man are discussed.
narcis.nl参考文章(38)
SM Reppert, MJ Perlow, LG Ungerleider, M Mishkin, L Tamarkin, DG Orloff, HJ Hoffman, DC Klein, Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey. The Journal of Neuroscience. ,vol. 1, pp. 1414- 1425 ,(1981) , 10.1523/JNEUROSCI.01-12-01414.1981
M Hines, FC Davis, A Coquelin, RW Goy, RA Gorski, Sexually dimorphic regions in the medial preoptic area and the bed nucleus of the stria terminalis of the guinea pig brain: a description and an investigation of their relationship to gonadal steroids in adulthood The Journal of Neuroscience. ,vol. 5, pp. 40- 47 ,(1985) , 10.1523/JNEUROSCI.05-01-00040.1985
Gary E. Pickard, The afferent connections of the suprachiasmatic nucleus of the golden hamster with emphasis on the retinohypothalamic projection The Journal of Comparative Neurology. ,vol. 211, pp. 65- 83 ,(1982) , 10.1002/CNE.902110107
R. M. Buijs, D. F. Swaab, J. Dogterom, F. W. van Leeuwen, Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat Cell and Tissue Research. ,vol. 186, pp. 423- 433 ,(1978) , 10.1007/BF00224932
F.-H. G�ldner, Numbers of neurons and astroglial cells in the suprachiasmatic nucleus of male and female rats Experimental Brain Research. ,vol. 50, pp. 373- 376 ,(1983) , 10.1007/BF00239203
Anthony N. Van Den Pol, Terry Powley, A fine-grained anatomical analysis of the role of the rat suprachiasmatic nucleus in circadian rhythms of feeding and drinking Brain Research. ,vol. 160, pp. 307- 326 ,(1979) , 10.1016/0006-8993(79)90427-X
G. Pickard, F. Turek, Splitting of the circadian rhythm of activity is abolished by unilateral lesions of the suprachiasmatic nuclei Science. ,vol. 215, pp. 1119- 1121 ,(1982) , 10.1126/SCIENCE.7063843
H.K. Hsu, M.T. Peng, Hypothalamic neuron number of old female rats. Gerontology. ,vol. 24, pp. 434- 440 ,(1978) , 10.1159/000212283
Herbert Haug, Brain sizes, surfaces, and neuronal sizes of the cortex cerebri: a stereological investigation of man and his variability and a comparison with some mammals (primates, whales, marsupials, insectivores, and one elephant). American Journal of Anatomy. ,vol. 180, pp. 126- 142 ,(1987) , 10.1002/AJA.1001800203
B. Roozendaal, W.A. van Gool, D.F. Swaab, J.E. Hoogendijk, M. Mirmiran, Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging Brain Research. ,vol. 409, pp. 259- 264 ,(1987) , 10.1016/0006-8993(87)90710-4