Acquired Coagulation Abnormalities and Thrombosis in Multiple Myeloma

摘要: textabstractMultiple Myeloma (MM) is a malignant plasma cell disorder which accounts for approximately 10% of the hematologic neoplasms(1, 2). In pathophysiology of MM, interaction between myeloma cells and bone marrow microenvironment leads to complex signalling network that sustains survival mediates tumour progression drug resistance. Major pathways involved are IL-6R/ STAT3, Ras/MAPK, PI3K/Akt, notch, WNT- NF-κB pathways(3). The cytokine interleukin-6 presumed play pivotal role in pathogenesis growth of MM(4) IL-6 levels elevated case active disease(5). also plays a stimulatory coagulation mechanism(6). It has been shown promote the transcription factor VIII gene(7), decrease protein S canine models(8), induce ultra large hyperreactive von Willebrand Factor(9), inhibit cleavage ultra large von Factor(6).