Brain banks as key part of biochemical and molecular studies on cerebral cortex involvement in Parkinson's disease.

摘要: Exciting developments in basic and clinical neuroscience recent progress the field of Parkinson’s disease (PD) are partly a result availability human specimens obtained through brain banks. These banks have optimized methodological, managerial organizational procedures; standard operating ethical, legal social issues, including code conduct for 21st Century banking novel protocols. The present minireview focuses on current organization management, as well likely future direction field. We emphasize potentials pitfalls when using high-quality central nervous system advancing PD research. is generalized which a-synuclein not unique component but, instead, only one players accounting complex impairment biochemical ⁄ molecular processes involved metabolic pathways. This particularly important cerebral cortex, where altered cognition has neurochemical substrate. Mitochondria energy metabolism impairment, abnormal RNA, microRNA, protein synthesis, post-translational modifications alterations lipid composition membranes rafts part these complementary factors. to be alert possible each specimen its suitability particular study. Not all samples qualify study DNA, proteins, modifications, lipids metabolomes, although use carefully selected appropriate methods minimizes errors guarantees reserach.