Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases
作者： Aline Ignacio , Camila Ideli Morales , Niels Olsen Saraiva Câmara , Rafael Ribeiro Almeida
关键词:
摘要: The mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of co-evolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia gut-associated immune cells thereby promoting the proper development mucosal system host homeostasis. Many studies demonstrated that host-microbiota play key role during local systemic immunity. Therefore, this review will focus on how sensing gut-microbiota metabolites through inflammasome toll-like impact modulation distinct set inflammatory autoimmune diseases. We believe better understanding fine-tuning governs further improve common prophylactic therapeutic applications.
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