Interplay among cytokines and T cell subsets in the progression and control of immune-mediated diseases
作者： Kamal D. Moudgil
DOI: 10.1016/J.CYTO.2015.05.006
关键词:
摘要: Cytokines serve as key mediators of inflammation and tissue damage in a variety immune-mediated disorders. The induction, progression, resolution such disorders are characterized by dynamic balance between both the pro-inflammatory anti-inflammatory cytokines well pathogenic protective T cell subsets. Over past two decades, roles interleukin-17 (IL-17) /IL-23 axis helper 17 (Th17)/ regulatory (Treg) pathogenesis autoimmunity other inflammatory diseases have extensively been analyzed, their significance validated. However, these studies, coupled with others devoted to well-established Th1/Th2 cytokines, unraveled some challenging issues including dual action plasticity Nevertheless, major positive advances also made regarding subsets therapeutic targets/agents. In this special issue, "Cytokines Immune Pathology Therapy," leading experts shared research work perspectives on development control diseases. An outline 14 articles first volume is presented here. second will follow soon.
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