The behavioral effects of nicotinamide adenine dinucleotide in chronic schizophrenia

作者: Herbert Meltzer , Richard Shader , Lester Grinspoon

DOI: 10.1007/BF00407047

关键词:

摘要: Two grams of NAD were administered orally to ten chronic schizophrenic patients for twenty-one days. Five the also receiving thioridazine. There was no gross clinical improvement noted in any despite fact that related experiments suggested absorbed. In those who not phenothiazines there a distinct tendency towards increased hostility, aggressiveness and irritability beginning one week after initiation treatment lasting nearly two weeks discontinued.

参考文章(14)
A. Goldin, R. A. Salvador, R. M. Burton, S. R. Humphreys, Interaction of nicotinamide with reserpine and chlorpromazine. II. Some effects on the central nervous system of the mouse. Archives internationales de pharmacodynamie et de thérapie. ,vol. 128, pp. 253- 259 ,(1960)
Oliver H. Lowry, Nira R. Roberts, Joyce I. Kapphahn, THE FLUOROMETRIC MEASUREMENT OF PYRIDINE NUCLEOTIDES Journal of Biological Chemistry. ,vol. 224, pp. 1047- 1064 ,(1957) , 10.1016/S0021-9258(18)64996-8
W. Ross Ashby, G. H. Collins, Margaret Bassett, The Effects of Nicotinic Acid, Nicotinamide, and Placebo on the Chronic Schizophrenic Journal of Mental Science. ,vol. 106, pp. 1555- 1559 ,(1960) , 10.1192/BJP.106.445.1555
M. Lorr, D. M. McNair, C. J. Klett, J. J. Lasky, Evidence of ten psychotic syndromes. Journal of Consulting Psychology. ,vol. 26, pp. 185- 189 ,(1962) , 10.1037/H0040653
JONAS COHLER, Behavioral Correlates of the Guessing Game Archives of General Psychiatry. ,vol. 15, pp. 279- 287 ,(1966) , 10.1001/ARCHPSYC.1966.01730150055009
Allan C. Goldstein, Samuel Eiduson, Edward Geller, Arthur Yuwiler, Bernice T. Eiduson, Biochemistry and behavior American Journal of Psychology. ,vol. 78, pp. 337- ,(1965) , 10.2307/1420526
A. Hoffer, H. Osmond, TREATMENT OF SCHIZOPHRENIA WITH NICOTINIC ACID. A TEN YEAR FOLLOW-UP. Acta Psychiatrica Scandinavica. ,vol. 40, pp. 171- 189 ,(1964) , 10.1111/J.1600-0447.1964.TB05744.X
James L. Framo, Arthur M. Adlerstein, A behavioral disturbance index for psychiatric patient and ward disturbance Journal of Clinical Psychology. ,vol. 17, pp. 260- 264 ,(1961) , 10.1002/1097-4679(196107)17:3<260::AID-JCLP2270170313>3.0.CO;2-E
LESTER GRINSPOON, JACK R. EWALT, RICHARD SHADER, Psychotherapy and Pharmacotherapy in Chronic Schizophrenia American Journal of Psychiatry. ,vol. 124, pp. 1645- 1652 ,(1968) , 10.1176/AJP.124.12.1645
N. S. Kline, G. L. Barclay, J. O. Cole, A. H. Esser, H. Lehmann, J. R. Wittenborn, Controlled Evaluation of Nicotinamide Adenine Dinucleotide in the Treatment of Chronic Schizophrenic Patients British Journal of Psychiatry. ,vol. 113, pp. 731- 742 ,(1967) , 10.1192/BJP.113.500.731