Fluid-percussion brain injury adversely affects control of vascular tone during hemorrhagic shock.

摘要: To test the hypothesis that brain injury impairs control of vascular tone during compensation from hemorrhagic shock, Sprague-Dawley rats underwent fluid-percussion (or sham control) followed by a stepwise hemorrhage period to 1/2 baseline mean arterial pressure (1/2 MAP), shock holding at MAP for 30 min, and resuscitation period. Aortic blood flow (ABF) was measured conductance (ABF/MAP) calculated. No differences occurred between groups During min period, controls decreased .2 +/- .07 .16 .04 required repeated additional (3.4 1.3 cc) maintain MAP. In contrast, brain-injured animals increased .21 .24 .06 (p < .05) fluid replacements (3.0 cc lactated Ringer's (LR), p Following resuscitation, appropriately .31 .05 in but did not change (.25 .04, animals. We conclude adversely affects this model.