Risk factors for colonisation of newborn infants during an outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in an intermediate-risk neonatal unit

摘要: Summary We describe a cross-sectional survey to identify risk factors for colonisation of neonates by extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae . This occurred following exposure colonised healthcare worker during an outbreak in intermediate-risk neonatal unit. In total, 120 admitted consecutively three-month period were screened ESBL-producing K. rectal swabbing and 27 identified as colonised. Multivariate analysis showed be independently associated with use antibiotics absence breastfeeding. Previous presented odds ratio (OR) 12.3 [95% confidence interval (CI): 3.66–41.2, P  = 0.049). Nine isolates recovered the first stage from surveillance cultures typed thereafter pulsed-field gel electrophoresis, revealing six different profiles (A–F). Clones A, C, E implicated outbreak, whereas among strains cultures, all clones identified. Clone A was also found on hand nursing auxiliary onychomycosis. concluded that prior antimicrobial predisposed colonisation. The possible role breastfeeding protective factor needs further elucidated. Detection genotypes suggests dissemination mobile genetic elements bearing ESBL gene may have been superimposed simple clone outbreak.