β‐lactam antibiotic resistance in aerobic commensal fecal flora of newborns

摘要: Background: The purpose of the present paper was to prospectively determine rate β-lactam antibiotic resistance in commensal fecal flora newborns and risk factors leading this colonization. Methods: One hundred eighteen neonatal intensive care unit (NICU) group (n = 38), ward (n = 36), control (n = 44) were enrolled. Three or four stool samples obtained from each infant, 15 days apart. Bacterial growth Eozin Methylene Blue (EMB) agar + 10 µg ampicillin/mL considered be ampicillin-resistant bacteria, susceptibility extended spectrum β-lactamases (ESBL) production investigated those bacteria. Results: Colonization with microorganisms determined 75.2% 367 samples. Klebsiella spp. Escherichia coli identified 59% 41% samples, respectively. The lowest bacterial colonization NICU group. Microorganisms producing ESBL 33.7% Fifty-one 73 E. coli isolates produce ESBL, There no difference respect ESBL-producing between three groups. When related evaluated through whole study period, very low birthweight, vaginal delivery, infant usage, maternal male sex premature rupture membranes as factors, while feeding nasogastric tube a protective factor. bacteria after discharge hospital evaluated, failure feed breast milk only factor. Conclusions: To decrease mortality morbidity due infection caused by resistant colonized intestine protection normal non-pathogenic is important. This can provided neonates milk, application measures efficiently, limitation usage strict clinical indications.