Immunolocalization of heat shock protein after fluid percussive brain injury and relationship to breakdown of the blood-brain barrier
作者： Hirokazu Tanno , Russ P. Nockels , Lawrence H. Pitts , Linda J. Noble
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摘要: We have previously developed a model of mild, lateral fluid percussive head injury in the rat and demonstrated that although this produced minimal hemorrhage, breakdown blood–brain barrier was prominent feature. The relationship between posttraumatic disruption cellular is unclear. In present study we examined distribution time course expression stress protein HSP72 after brain compared these findings with known pattern similar injury. Rats were subjected to (4.8–5.2 atm, 20 ms) killed at 1, 3, 6 h 1,3, 7 days HSP72-like immunoreactivity evaluated sections light-microscopic level. earliest occurred 3 postinjury restricted neurons glia cortex surrounding necrotic area impact site. By h, light immunostaining also noted in...
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