Prevention of meningococcal disease.

摘要: Neisseria meningitidis is the most common cause of meningitis in children aged 2–18 with a mortality rate ranging from 4–40% and substantial morbidity 11–19% survivors. Of four serogroups meningitidis, B C are causes United States, serogroup causing disease among adolescents, population at risk for invasive meningococcal disease. The polysaccharide vaccine was developed response to increasing rates bacterial military recruits. With widespread use military, there dramatic decreased incidence However, may be limitations including lack durable protection, induction T-cell-dependent immune response, immunogenicity less than 2 years age. Based on success other conjugate vaccines pediatrics, new vaccine, Menactra®, has been app...