Multinucleated giant cell appearance after whole body microwave irradiation of rats

作者: Ivančica Trošić

DOI: 10.1078/1438-4639-00078

关键词:

摘要: Abstract Multinucleated giant cells are common for some chronic inflammatory processes in the lung. These formed by fusion of macrophages, but how process relates to kinetics alveolar macrophage generation is not clear. This study investigated influence 2450 MHz microwave irradiation on and formation multinucleated after whole body rats. The range electromagnetic radiation was selected as microwaves at a power density 5 – 15mW/cm2. A group experimental animals divided four subgroups that received 2, 8, 13 22 treatments two hours each. were killed days 1, 16, 30. Free lung cell population obtained bronchoalveolar lavage. Cell response level followed quantitatively, qualitatively morphologically using standard laboratory methods. Total number retrieved lavage slightly decreased treated showing time- dose-dependence. viability did significantly change irradiated animal (G2) compared with control (G1). increased (p

参考文章(14)
Željko Radalj, Ivančica Trošić, Mirjana Mataušić-Pišl, Ivica Prlić, Animal study on electromagnetic field biological potency. Arhiv Za Higijenu Rada I Toksikologiju. ,vol. 50, pp. 5- 11 ,(1999)
G. Oberdörster, J.L. Mauderly, D. L. Dungworth, Toxic and carcinogenic effects of solid particles in the respiratory tract ILSI Press. ,(1994)
D H Bowden, The alveolar macrophage. Environmental Health Perspectives. ,vol. 55, pp. 327- 341 ,(1984) , 10.1289/EHP.8455327
Ivančica Trošić, Mirjana Mataušić-Pišl, Danijela Vučinić, Macrophage phagocytic activity and cell phagocytic capacity following intratracheal instillation of a comixture of asbestos fibers Experimental and Toxicologic Pathology. ,vol. 47, pp. 238- 240 ,(1995) , 10.1016/S0940-2993(11)80256-3
Richard B. Johnston, Current concepts: immunology. Monocytes and macrophages. The New England Journal of Medicine. ,vol. 318, pp. 747- 752 ,(1988) , 10.1056/NEJM198803243181205
Ivančica Trošić, Mirjana Mataušić-Pišl, Nada Horš, I. Trošić, Pathways and quantification of insoluble particles in the lung compartments of the rat International Journal of Hygiene and Environmental Health. ,vol. 203, pp. 39- 43 ,(2000) , 10.1078/S1438-4639(04)70006-1
Elliott Kagan, Yoichi Oghiso, Dan-Paul Hartmann, The effects of chrysotile and crocidolite asbestos on the lower respiratory tract: analysis of bronchoalveolar lavage constituents. Environmental Research. ,vol. 32, pp. 382- 397 ,(1983) , 10.1016/0013-9351(83)90120-2
James H. Dauber, Milton D. Rossman, Ronald P. Daniele, Pulmonary fibrosis: bronchoalveolar cell types and impaired function of alveolar macrophages in experimental silicosis. Environmental Research. ,vol. 27, pp. 226- 236 ,(1982) , 10.1016/0013-9351(82)90074-3
John R. Spurzem, Cesare Saltini, William Rom, Robert J. Winchester, Ronald G. Crystal, Mechanisms of Macrophage Accumulation in the Lungs of Asbestos-Exposed Subjects The American review of respiratory disease. ,vol. 136, pp. 276- 280 ,(1987) , 10.1164/AJRCCM/136.2.276