Molecular Profiles of Pre- and Postoperative Breast Cancer Tumours Reveal Differentially Expressed Genes

摘要: Gene expression studies on breast cancer have generally been performed tissue obtained at the time of surgery. In this study, we compared gene profiles in preoperative (core needle biopsies) while tumor is still its normal milieu to postoperative from same during Thirteen patients were included which eleven had undergone sentinel node diagnosis procedure before operation. Microarray analysis was using total RNA all samples. Paired significance microarrays revealed 228 differently expressed genes, including several early response stress-related genes such as members fos and jun families well has previously associated with cancer. The found analyses must be evaluated caution. Different may simply result differences surgical trauma timing when samples are taken not necessarily biology.