Low free testosterone levels predict disease reclassification in men with prostate cancer undergoing active surveillance

摘要: Objective To determine whether total testosterone and free levels predict disease reclassification in a cohort of men with prostate cancer (PCa) on active surveillance (AS). Patients Methods Total concentrations were determined at the time began AS protocol. Statistical analysis was performed using Student's t-test chi-squared test to compare groups. Odds ratios (ORs) 95% confidence intervals (CIs) obtained univariate logistic regression. Receiver–operator characteristic curves generated investigated thresholds. Kaplan–Meier used estimate reclassification. A Cox proportional hazard regression model for multivariate analysis. Results A 154 included cohort, whom 54 (35%) progressed treatment. Men who had significantly lower than those not reclassified (0.75 vs 1.02 ng/dL, P = 0.03). <0.45 ng/dL higher rate patients ≥0.45 (P 0.032). Free associated several-fold increase risk (OR 4.3, CI 1.25–14.73). Multivariate showed that family history PCa independent predictors reclassification. Conclusions Free during AS. moderately severe reductions level are increased