Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice.
作者： Tokumitsu Watanabe , Takahiro Sato , Tomokazu Amano , Yumiko Kawamura , Naohiro Kawamura
DOI: 10.1002/DVDY.21787
关键词:
摘要: Dnm3os, a gene that is transcribed into non-coding RNA (ncRNA), contains three micro RNAs (miRNAs), miR-199a, miR-199a*, and miR-214, whose functions remain unknown in mammals. In this study, we introduced the lacZ Dnm3os locus to recapitulate its expression pattern disrupt function. Dnm3os+/lacZ heterozygous embryos showed β-galactosidase activity, which reflected authentic of RNA. Most Dnm3oslacZ/lacZ homozygous pups died within one month birth. After birth, mice exhibited several skeletal abnormalities, including craniofacial hypoplasia, defects dorsal neural arches spinous processes vertebrae, osteopenia. Importantly, miR-214 was significantly down-regulated embryos, supporting assumption serves as precursor these miRNAs. Thus, has emerged an miRNA-encoding indispensable for normal development body growth Developmental Dynamics 237:3738–3748, 2008. © 2008 Wiley-Liss, Inc.
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