Vitamin A and aflatoxin: effect on liver and colon cancer.
作者： Voranunt S. Suphakarn , Paul M. Newberne , Mark Goldman
DOI: 10.1080/01635588309513777
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摘要: Abstract A vitamin (retinyl acetate)‐deficient diet enhanced liver cancer in rats exposed to aflatoxin B1 (AFB1) and also caused a 29% incidence of colon cancer. The following factors were considered attempts define conditions under which vitamin‐A‐deprived more susceptible induced by AFB1: morphology, enterohepatic recirculation, level reduced glutathione (GSH) liver, differing capacities for conjugation GSH. Enzyme concentrations intestinal mucosa, contents suggested that AFB1 may have different metabolites there be susceptibilities mucosa carcinogenesis. Binding studies supported this hypothesis. Previous shown epithelium from vitamin‐A‐deficient binds than normal, vitamin‐A‐supplemented animals. In the present study, supplementation before oral admini...
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