作者: Robert Y Lin , Mark E. Astiz , James C. Saxon , Eric C. Rackow
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摘要: To evaluate the role of cellular activation markers and functional surface molecules in sepsis, specific immunophenotypes on peripheral blood leukocytes were studied 40 subjects consisting following: (1) patients with septic shock; (2) sepsis; (3) critically ill nonseptic patients; (4) normal control subjects. These assays included phagocyte adhesion molecule CD11b expression, monocyte receptors HLA-DR CD14, lymphocyte IL-2R HLA-DR. Patients shock sepsis had significantly increased neutrophil expression compared Neutrophil did not differ between groups. Monocytes from less than diere was a trend toward lower proportion gated monocytes that expressed CD14 patients. Septic no significant increases or CD3 lymphocytes subjects, but they numbers total, CD3, CD4, CD8 higher prevalence anergy. manifested an increase may play organ injury. In contrast, more decrease antigens is also observed have implications for immunologic defense mechanisms.