Altered Leukocyte Immunophenotypes in Septic Shock: Studies of HLA-DR, CD11b, CD14, and IL-2R Expression

作者: Robert Y Lin , Mark E. Astiz , James C. Saxon , Eric C. Rackow

DOI: 10.1378/CHEST.104.3.847

关键词:

摘要: To evaluate the role of cellular activation markers and functional surface molecules in sepsis, specific immunophenotypes on peripheral blood leukocytes were studied 40 subjects consisting following: (1) patients with septic shock; (2) sepsis; (3) critically ill nonseptic patients; (4) normal control subjects. These assays included phagocyte adhesion molecule CD11b expression, monocyte receptors HLA-DR CD14, lymphocyte IL-2R HLA-DR. Patients shock sepsis had significantly increased neutrophil expression compared Neutrophil did not differ between groups. Monocytes from less than diere was a trend toward lower proportion gated monocytes that expressed CD14 patients. Septic no significant increases or CD3 lymphocytes subjects, but they numbers total, CD3, CD4, CD8 higher prevalence anergy. manifested an increase may play organ injury. In contrast, more decrease antigens is also observed have implications for immunologic defense mechanisms.

参考文章(40)
Robert F. Todd, David R. Freyer, The CD11/CD18 Leukocyte Glycoprotein Deficiency Hematology/Oncology Clinics of North America. ,vol. 2, pp. 13- 31 ,(1988) , 10.1016/S0889-8588(18)30629-4
L J Picker, T A Gonwa, J D Stobo, J Silver, S M Goyert, H V Raff, Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR Journal of Immunology. ,vol. 130, pp. 706- 711 ,(1983)
J J Oppenheim, H M Johnson, P S Steeg, Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: inhibitory effect of endotoxin. Journal of Immunology. ,vol. 129, pp. 2402- 2406 ,(1982)
Fridtjof Lund-Johansen, Johanna Olweus, Ånen Aarli, Robert Bjerknes, Signal transduction in human monocytes and granulocytes through the PI-linked antigen CD14 FEBS Letters. ,vol. 273, pp. 55- 58 ,(1990) , 10.1016/0014-5793(90)81049-T
Guy A Zimmerman, Stephen M Prescott, Thomas M McIntyre, Endothelial cell interactions with granulocytes: tethering and signaling molecules Immunology Today. ,vol. 13, pp. 93- 100 ,(1992) , 10.1016/0167-5699(92)90149-2
M B Fasano, S Cousart, S Neal, C E McCall, Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome. Journal of Clinical Investigation. ,vol. 88, pp. 1452- 1459 ,(1991) , 10.1172/JCI115454
C. Birkenmaier, Y. S. Hong, J. K. Horn, Modulation of the endotoxin receptor (CD14) in septic patients. Journal of Trauma-injury Infection and Critical Care. ,vol. 32, pp. 473- 479 ,(1991) , 10.1097/00005373-199107000-00033
MASAKO K. NISHIJIMA, JUN TAKEZAWA, KIKUMI K. HOSOTSUBO, HIDEO TAKAHASHI, YASUHIRO SHIMADA, IKUTO YOSHIYA, Serial changes in cellular immunity of septic patients with multiple organ-system failure. Critical Care Medicine. ,vol. 14, pp. 87- 91 ,(1986) , 10.1097/00003246-198602000-00002
H.Hank Simms, R. D'Amico, Increased PMN CD11b/CD18 expression following post-traumatic ARDS Journal of Surgical Research. ,vol. 50, pp. 362- 367 ,(1991) , 10.1016/0022-4804(91)90204-Y