Diet carotenoid lutein modulates the expression of genes related to oxygen transporters and decreases DNA damage and oxidative stress in mice

摘要: Lutein (LT) is a carotenoid obtained by diet and despite its antioxidant activity had been biochemically reported, few studies are available concerning influence on the expression of genes. The 84 genes implicated in defense was quantified using quantitative reverse transcription polymerase chain reaction array. DNA damage measured comet assay glutathione (GSH) thiobarbituric acid reactive substances (TBARS) were as biochemical parameters oxidative stress mouse kidney liver. cDDP treatment reduced concentration GSH increased TBARS, that ameliorated associated with LT. altered 32 genes, increasing GPx2, APC, Nqo1 CCs. LT changed 37 an induction 13 mainly oxygen transporters. In treatments associating LT, 30 their increase same alone. These results suggest might act scavenging species also inducing related to better response, highlighting improvement transport. This improved redox state cell through could be antigenotoxic effects observed.