Acute nephrotoxicity of cisplatin: molecular mechanisms
作者： Luis Alberto Batista Peres , Ademar Dantas da Cunha Júnior
DOI: 10.5935/0101-2800.20130052
关键词:
摘要: The nephrotoxic drugs have been responsible for about 20% of AKI episodes in inpatients and outpatients. cisplatin nephrotoxicity is a major limiting factors patients who received the drug, triggering injuries renal tubular epithelial cells. Cisplatin toxicity determined by target tissue cells accumulation besides interaction with various subcellular structures macromolecules. accumulates interferes functioning different organelles such as mitochondria, lysosomes, endoplasmic reticulum, nuclei cell membranes, causing inflammation death. This review aims to define pathophysiology biochemistry nephrotoxicity, reviewing main molecular mechanisms that lead toxicity.
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