Cell-Based Therapy for Degenerative Retinal Disease
作者： Marco Zarbin
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摘要: Stem cell-derived retinal pigment epithelium (RPE) and photoreceptors (PRs) have restored vision in preclinical models of human degenerative disease. This review discusses characteristics stem cell therapy the eye challenges to clinical implementation that are being confronted today. Based on encouraging results from Phase I/II trials, first II trials RPE transplantation underway. PR transplant experiments demonstrated restoration visual function retinitis pigmentosa macular degeneration, but also indicate no single approach is likely succeed overcoming loss all cases. A greater understanding mechanisms controlling synapse formation as well immunoreactivity transplanted cells urgently needed.
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openlibrary.org参考文章(154)
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