Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression.
作者： Duygu Dee Harrison-Findik , Sizhao Lu , Emily M Zmijewski , Jocelyn Jones , Matthew C Zimmerman
关键词:
摘要: AIM: To understand the role of mitochondrial-produced superoxide (O2 •- ) in regulation iron-regulatory hormone, hepcidin by alcohol liver. METHODS: For experiments, manganese su- peroxide dismutase knockout mice heterozygous for Sod2 gene expression (Sod2 +/- and age-matched lit- termate control (LMC), expressing on both alleles, were exposed to either 10% (w/v) ethanol drinking water or plain (control) 7 d. Total cellular O2
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