Entamoeba histolytica activates host cell caspases during contact-dependent cell killing.
作者： D. R. Boettner , W. A. Petri
关键词:
摘要: Entamoeba histolytica is a human intestinal parasite that causes amoebic colitis as well liver abscesses. Host tissues are damaged through three-step process involving adherence, contact-dependent cytolysis, and phagocytosis. These three processes all contribute to the pathogenicity of this parasite. Adherence provided by Gal/GalNAc adherence lectin. cells lysed in fashion. There evidence suggests killing involves induction host cell’s apoptotic machinery. Phagocytosis can then occur, consistent with metazoan clearance.
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