Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis.

摘要: White matter (WM) lesions are the classic pathological hallmarks of multiple sclerosis (MS). However, MRI-based WM lesion load shows relatively poor correlation with functional outcome, resulting in "clinico-radiological paradox" MS. Unlike based measures, volumetric MRI assessment brain atrophy a strong and presence early predicts worse disease course. While extensive literature exists describing characteristics MS, exact pathogenesis substrate atrophy-gray vs. loss, axonal/neuronal damage demyelination, or combination above-remain unclear. Animal models would allow for detailed investigations pathomechanism, contribute to an enhanced understanding structural-functional connections this complex disease. We now report that Theiler's Murine Encephalitis Virus (TMEV) model MS SJL/J mice, significant accompanies development progressive MS-like conducted studies 8 cases 4 age, gender- strain-matched control mice. controls we did not detect any atrophy, developed as 3 months into course, reached its peak by 6 months, ventricular enlargement 118% (p=0.00003). A (r=-0.88) between disability, assessed rotarod assay, was also demonstrated. earlier reported another neurodegenerative feature model, deep gray T2 hypointensity thalamic nuclei. Future utilizing will us investigate key components detectable development, their tissue correlations associations outcome measures. These expected pave way better disability models.