Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis.

摘要: Brain atrophy measured by MRI is an important correlate with clinical disability and disease duration in multiple sclerosis (MS). Unfortunately, neuropathologic mechanisms which lead to this grey matter remain unknown. The objective of study was determine whether brain occurs the mouse model, experimental autoimmune encephalomyelitis (EAE). Postmortem high-resolution T2-weighted magnetic resonance microscopy (MRM) images from 32 brains (21 EAE 11 control) were collected. A minimum deformation atlas constructed a deformable approach used quantify volumetric changes neuroanatomical structures. significant decrease mean cerebellar cortex volume mice late (48–56 days after induction) as compared normal strain, gender, age-matched controls observed. There direct correlation between cortical duration. At early time point disease, 15 induction, white lesions detected both histology MRM. These data demonstrate that myelin-specific responses can otherwise CNS. model described herein now be investigate development gray setting.