Pathology-guided MR analysis of acute and chronic experimental allergic encephalomyelitis spinal cord lesions at 1.5T.
作者： Lisa L. Cook , Paula J. Foster , Stephen J. Karlik
DOI: 10.1002/JMRI.20368
关键词: Spinal cord 、 Biopsy 、 Lesion 、 Fluid-attenuated inversion recovery 、 Encephalomyelitis 、 Immunohistochemistry 、 Experimental pathology 、 Medicine 、 Pathology 、 In vivo
摘要: Purpose To directly correlate spinal cord pathology of guinea pigs with experimental allergic encephalomyelitis (EAE) to the MRI data obtained at 1.5T. Materials and Methods Spinal cords from EAE animals were imaged in vivo following sequences: T2-FSE, PD-FSE, fluid-attenuated inversion recovery (FLAIR)-FSE, T2-CSE, T1-CSE, T1-CSE + gadolinium-DTPA (Gd-DTPA), PD-CSE, short-tau (STIR)-FSE. The removed lesions specific pathological compositions identified by histological analysis. Regions interest (ROIs) drawn on corresponding MR images, signal-to-noise ratios (SNRs) measured for each sequence compared controls. Results The receiver operating characteristic (ROC) analysis STIR-FSE PD-CSE was able differentiate tissue that contained cellular infiltrates a high degree accuracy. SNRs STIR-FSE, Gd-DTPA elevated alone, whereas reduced demyelinated also inflammation. Conclusion The SNR difference between two lesion groups suggests combination sequences may be useful differentiating inflammatory containing demyelination inflammation alone. J. Magn. Reson. Imaging 2005;22:180–188. © 2005 Wiley-Liss, Inc.
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