Detection of human papillomavirus DNA in tumors from Rwandese breast cancer patients.

摘要: During the last decades, a great interest was given to viral etiology of breast cancer. Indeed, due recent technical improvements and some encouraging new results, it has been resurgence in possibility that substantial proportion human cancers may be caused by infections. High-risk genotypes papillomavirus (HPV) have found cancer cases. In present study, we aimed assess presence HPV DNA cases from Rwanda evaluate association between infection clinico-pathological features. Therefore, total 47 archived formalin-fixed paraffin-embedded biopsies were collected complete information recorded. detection genotyping done PCR amplification sequencing. Overall, 46.81% cases, HPV16 being most prevalent subtype (77.27%) followed HPV33 (13.64%) HPV31 (9.09%). Comparison with features showed no significant difference localization, histological subtype, clinical stage, tumor grade, intrinsic molecular subtypes. These findings provide evidence high prevalence high-risk Rwandese patients suggest infections could risk factor associated development.