Silver salts of carboxylic acid terminated generation 1 poly (propyl ether imine) (PETIM) dendron and dendrimers as antimicrobial agents against S. aureus and MRSA

摘要: Novel therapeutic strategies are essential to address the current global antimicrobial resistance crisis. Branched molecules with multiple peripheral functionalities, known as dendrimers, have gained interest antimicrobials and varying levels of toxicity. Silver displays activity against several micro-organisms only in its positively charged form. In this study, silver salts generation 1 (G1) poly (propyl ether imine) (PETIM) dendron dendrimers were synthesised evaluated for their potential sensitive resistant bacteria. The purpose was exploit functionalities G1 PETIM formation containing ions a single molecule enhanced at lowest possible concentration. dendron, characterised by FT-IR, 1H NMR 13C NMR. Hep G2, SKBR-3 HT-29 cell lines cytotoxicity using MTT assay. dendron/dendrimers, nitrate (compound 13), dendrimer an aromatic core 14) oxygen 15) S. aureus methicillin-resistant (MRSA) broth dilution method. found be non-cytotoxic even up 100 μg ml−1. Minimum inhibitory concentration values compounds 13, 14 15 52.1, 41.7 20.8 ml−1 while MRSA they 125.0, 26.0 62.5 ml−1, respectively. calculated fractional index further indicated that compound specifically displayed additive effects synergism MRSA. activities dendron/dendrimer-silver both bacterial strains widen pool available pharmaceutical materials optimizing treatment infections.