Quality of life in long-term survivors of CNS tumors of childhood and adolescence.

摘要: Clinical reports of small numbers pediatric brain tumor patients observed for brief periods suggest that long-term survivors continue to have major handicaps into adulthood. To quantify these late effects we interviewed 342 adults (or their proxies) who had CNS tumors diagnosed before the age 20 between 1945 and 1974, survived at least 5 years, reached 21 years age. Survivors were 32 old on average follow-up. When compared with 479 matched siblings as controls. more likely died or become mentally incompetent sometime during follow-up period. They be risk such adverse outcomes unemployment (odds ratio [OR], 10.8; 95% confidence interval [CI], 4.6 25.7], a health condition affected ability work (OR, 5.9; CI, 3.7 9.4), unable drive 28.8; 6.9 119.9), describe current poor 7.8; 1.7 35.7). Unfavorable frequent in male than females, those supratentorial infratentorial ones, received radiation therapy. As clinicians consider improving therapies, they should anticipate effects, observed, attempt target subgroups interventions may improve subsequent quality life.