In Vitro Analysis of Epithelial Surface Changes During Implantation

摘要: Blastocyst implantation involves interaction between two independently controlled yet highly interdependent systems, the embryo and its maternal environment. In rodents preimplantation blastocyst becomes closely surrounded by uterine epithelium in an “implantation chamber” (Enders, 1975), which precedes first irreversible uterus — adhesion apical surfaces of embryonic (trophectoderm) (“1” Figure 1). mice, occurs about 100 hours after morning coital vaginal plug is discovered (Potts, 1968). rats this brought a nidatory surge estradiol, accompanying increasing levels progesterone (Psychoyos, 1973). There no clear separation time appearance initiation basolateral changes, occur 3.5 4.5 days mating (“2” These changes are characterized loosening lateral cell associations, involving ultimately junctional complexes (“3” 1) from basal lamina (Schlafke et al., 1985), preparatory to subsequent sloughing death (Parr 1987).