Increased coronary arterial release of interleukin-1 receptor antagonist and soluble CD40 ligand indicative of inflammation associated with culprit coronary plaques.

摘要: Blood taken from the coronary artery ostium reflects biochemical changes indicative of thrombosis in culprit vessel. We sought to determine whether inflammation is manifested by increased concentrations selected markers ostial blood sampled a proximal an atherosclerotic plaque. The C-reactive protein (CRP), interleukin (IL)-6, IL-1 receptor antagonist, and soluble CD40 ligand (sCD40L) were measured drawn 75 patients before percutaneous intervention femoral guide catheter after engagement artery. Results compared using Student's t tests. An acute syndrome was present 88% patients. CRP IL-6 similar peripheral blood. Concentrations antagonist consistently greater arterial with (peripheral 545 ± 378 vs 595 388 pg/ml, p = 0.003). sCD40L also 0.80 0.46 2.12 2.77 ng/ml, <0.0001). concentration that suggests these cytokines contribute directly response may potentiate systemic inflammatory state.