Reactive Oxygen Species as Costimulatory Signals of Cytokine-Induced NF-κ B Activation Pathways
作者： Patrick A. Baeuerle
DOI: 10.1016/B978-012636670-9/50010-6
关键词:
摘要: Inflammation relies on the coordinated expression of numerous genes in response to primary and secondary inflammatory stimuli. Transcription factor NF- κ B has been recognized as a central regulator that is activated not only by proinflammatory cytokines Tumor Necrosis Factor-α(TNF-α) Interleukin-1 β (IL-1 ) but also many other pathogenic conditions. Among activators are oxidants conditions causing prooxidant state cells, such radiation, transition metals, toxins. In instances, administration antioxidants or expressions antioxidative enzymes found prevent activation. This chapter investigates at molecular level how affect activation, which they act cytokine-induced pathways. It reviews most recent insights into activation pathways discusses model Reactive Oxygen Species (ROS) important costimulatory signals rather than second messengers these
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