NF-κB: A Mediator of Pathogen and Stress Responses

摘要: The transcription factor NF-κB is a central regulator of defensive responses which are mounted by cells against many potentially threatening environmental challenges. Bacteria, viruses, parasites, injury, radiation, oxidative stress, numerous chemical agents and cytokines released in response to such challenges all well-studied potent activators this number different cell types. Activated then induces the expression genes whose encoded functions play critical roles for defense organism. induced proteins have wide range activities, including antibacterial or anti-viral functions, antigen recognition, cellular migration adhesion as well hematopoietic differentiation proliferation. Aside from regulating genes, several human immunodeficiency virus, diverted their own purposes. Since regulated NF-κB, appears coordinated response. In an evolutionary sense, association between dates at least far back insects.