Sensitization to airborne environmental allergens: unresolved issues

作者: P G Holt , W R Thomas

DOI: 10.1038/NI1005-957

关键词:

摘要: Despite considerable advances in identifying the environmental agents that trigger allergy and immunological mechanisms involved, progress developing effective treatments remains frustratingly slow. Is it time to rethink some of paradigms guiding this research?

参考文章(30)
Catherine A. Thornton, John W. Upham, Matthew E. Wikström, Barbara J. Holt, Gregory P. White, Mary J. Sharp, Peter D. Sly, Patrick G. Holt, Functional Maturation of CD4+CD25+CTLA4+CD45RA+ T Regulatory Cells in Human Neonatal T Cell Responses to Environmental Antigens/Allergens Journal of Immunology. ,vol. 173, pp. 3084- 3092 ,(2004) , 10.4049/JIMMUNOL.173.5.3084
Michael Croft, Paul R. Rogers, Peptide Dose, Affinity, and Time of Differentiation Can Contribute to the Th1/Th2 Cytokine Balance Journal of Immunology. ,vol. 163, pp. 1205- 1213 ,(1999)
Roger P Lauener, Thomas Birchler, Jill Adamski, Charlotte Braun-Fahrländer, Albrecht Bufe, Udo Herz, Erika von Mutius, Dennis Nowak, Josef Riedler, Marco Waser, Felix H Sennhauser, Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children The Lancet. ,vol. 360, pp. 465- 466 ,(2002) , 10.1016/S0140-6736(02)09641-1
Julie Rowe, Tricia Heaton, Merci Kusel, Devinda Suriyaarachchi, Michael Serralha, Barbara J Holt, Nick de Klerk, Peter D Sly, Patrick G Holt, High IFN-γ production by CD8+ T cells and early sensitization among infants at high risk of atopy The Journal of Allergy and Clinical Immunology. ,vol. 113, pp. 710- 716 ,(2004) , 10.1016/J.JACI.2003.12.585
Markus Grewe, Carla A.F.M Bruijnzeel-Koomen, Erwin Schöpf, Theo Thepen, Alice G Langeveld-Wildschut, Thomas Ruzicka, Jean Krutmann, A Role for Th1 and Th2 Cells in the Immunopathogenesis of Atopic Dermatitis Immunology Today. ,vol. 19, pp. 359- 361 ,(1998) , 10.1016/S0167-5699(98)01285-7
Patrick G. Holt, Jonathon D. Sedgwick, Suppression of IgE responses following inhalation of antigen Immunology Today. ,vol. 8, pp. 14- 15 ,(1987) , 10.1016/0167-5699(87)90825-5
Menachem Rottem, Martine Szyper-Kravitz, Yehuda Shoenfeld, Atopy and asthma in migrants. International Archives of Allergy and Immunology. ,vol. 136, pp. 198- 204 ,(2005) , 10.1159/000083894
Wayne R. Thomas, Belinda J. Hales, Wendy-Anne Smith, Structural biology of allergens. Current Allergy and Asthma Reports. ,vol. 5, pp. 388- 393 ,(2005) , 10.1007/S11882-005-0012-1
P. G. Holt, C. Macaubas, P. A. Stumbles, P. D. Sly, The role of allergy in the development of asthma Nature. ,vol. 402, pp. 12- 17 ,(1999) , 10.1038/35037009
Verena Niederberger, Petra Stübner, Susanne Spitzauer, Dietrich Kraft, Rudolf Valenta, Klaus Ehrenberger, Friedrich Horak, Skin Test Results but not Serology Reflect Immediate Type Respiratory Sensitivity: A Study Performed with Recombinant Allergen Molecules Journal of Investigative Dermatology. ,vol. 117, pp. 848- 851 ,(2001) , 10.1046/J.0022-202X.2001.01470.X