Effects of nicotine on finger tapping rate in non-smokers.
作者： R.J. West , M.J. Jarvis
DOI: 10.1016/0091-3057(86)90377-1
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摘要: Abstract Five experiments were conducted investigating the effects of nicotine on finger tapping rate in non-smokers. In each experiment subjects tapped as fast possible a fixed number times with one conventional computer keyboard. first was increased by two 2 mg doses nasal solution (NNS) but not an inactive solution. The second study carried out double-blind and showed that single dose NNS improved performance about 5% whereas very low (0.15 mg) placebo had no effect. effect to bring sustained increase from start trial. third found reduced 2.5 central cholinergic blocking agent, mecamylamine, placebo. Experiments four followed for hour after within subject this behavioral measure can provide consistent sensitive bio-assay time course effects. final repeated dosing hourly schedule six hours produced reliable speed evidence acute tolerance. results indicate substantially improve bynon-smokers simple motor task, probably via its action pathways. provides effective means examining
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