Diagnosis and management of primary autoimmune neutropenia in children: insights for clinicians

摘要: Autoimmune neutropenia of infancy (AIN), also called primary autoimmune neutropenia, is a disease in which antibodies recognize membrane antigens neutrophils, mostly located on immunoglobulin G (IgG) Fc receptor type 3b (FcγIIIb receptor), causing their peripheral destruction. It the most frequent children under 3–4 years age and cases shows benign, self-limited course. The diagnosis based evidence indirect antineutrophil antibodies, whose detection frequently remains difficult. In this review we have analyzed literature regarding AIN present our personal experience management.