Interpreting different measures of glomerular filtration rate in obesity and weight loss: pitfalls for the clinician

摘要: To combat the increasing incidence of obesity, much research has been devoted to devising successful strategies for weight loss, including manipulation diet and gastric surgery. Obesity itself can be associated with renal dysfunction, degree reversibility this loss being studied. However, there are significant limitations flaws in methods we have available measure glomerular filtration rate (GFR) overweight obese subjects. is changes body composition lean fat mass. This implications assumptions that underpin creatinine-based measures such as creatinine clearance, estimated GFR other equations devised obesity Salazar-Corcoran equation. These also affect cystatin C nuclear medicine isotope scans. article will review accuracy these current function consider evidence adjusting surface area or Finally, effect on serial measurements a given individual, independent true change function, reviewed. Ultimately using Cockcroft-Gault equation an adjustment mass seems best obesity. No method measuring situations shown unequivocally superior.