Eosinophilic fasciitis. A pathologic study of twenty cases.

摘要: This report presents a detailed light-microscopic evaluation of biopsies obtained from 20 patients with eosinophilic fasciitis, newly recognized disorder characterized by inflammation and thickening the deep fascia, hypergammaglobulinemia, peripheral tissue eosinophilia. Early in course disease, fascia lower subcutis are edematous infiltrated lymphocytes, plasma cells, histiocytes, eosinophils; these features associated impressive As illness progresses, structures eventually dermis become collagenized, thickened, sclerotic. Tissue eosinophilia may be focal or diffuse is usually observed and/or subcutis. Extracutaneous involvement has been limited to chronic synovitis tenosynovitis, latter frequently carpal tunnel syndrome. Deposits immunoglobulin complement were found five eight studied direct immunofluorescence, which suggests that an immunologic stimulus responsible for initiating this Differential diagnoses discussed.