Gene expression profile in diagnostics

作者: Vanessa Dumeaux , Eiliv Lund

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摘要: The present invention provides a method for diagnosing, identifying or monitoring proliferative disorders due to e.g cancer preferably breast in subject by measuring the change of gene expression sample e.g. blood sample. also encompasses oligonucleotide probes and primers corresponding genes differentially expressed compared pattern normal cell. use such oligonucleotides is an aspect together with kit comprising said oligonucleotides.

参考文章(52)
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Michael Rebhan, Vered Chalifa-Caspi, Jaime Prilusky, Doron Lancet, GeneCards: integrating information about genes, proteins and diseases Trends in Genetics. ,vol. 13, pp. 163- 163 ,(1997) , 10.1016/S0168-9525(97)01103-7
J.R. WARNER, J. VILARDELL, J.H. SOHN, Economics of ribosome biosynthesis. Cold Spring Harbor Symposia on Quantitative Biology. ,vol. 66, pp. 567- 574 ,(2001) , 10.1101/SQB.2001.66.567
Mina J. Bissell, Derek Radisky, Putting tumours in context Nature Reviews Cancer. ,vol. 1, pp. 46- 54 ,(2001) , 10.1038/35094059
Craig B. Thompson, Kenneth A. Frauwirth, Activation and inhibition of lymphocytes by costimulation Journal of Clinical Investigation. ,vol. 109, pp. 295- 299 ,(2002) , 10.1172/JCI14941
Kazue Imai, Satoru Matsuyama, Satoshi Miyake, Kenji Suga, Kei Nakachi, Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population The Lancet. ,vol. 356, pp. 1795- 1799 ,(2000) , 10.1016/S0140-6736(00)03231-1
Jeffrey C. Rathmell, Mathew G.Vander Heiden, Marian H. Harris, Kenneth A. Frauwirth, Craig B. Thompson, In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Molecular Cell. ,vol. 6, pp. 683- 692 ,(2000) , 10.1016/S1097-2765(00)00066-6
Jan van Riggelen, Alper Yetil, Dean W. Felsher, MYC as a regulator of ribosome biogenesis and protein synthesis Nature Reviews Cancer. ,vol. 10, pp. 301- 309 ,(2010) , 10.1038/NRC2819
Paul Anderson, None, Post-transcriptional regulons coordinate the initiation and resolution of inflammation Nature Reviews Immunology. ,vol. 10, pp. 24- 35 ,(2010) , 10.1038/NRI2685
Sandra Sacre, Mino Medghalchi, Bernard Gregory, Fionula Brennan, Richard Williams, Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll‐like receptors Arthritis & Rheumatism. ,vol. 62, pp. 683- 693 ,(2010) , 10.1002/ART.27304