Mechanical and Systems Biology of Cancer

摘要: Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, survival. The dynamics interactions of cytoskeletal components control basic mechanical properties, such as tension, stiffness, engagement with the extracellular environment, which can lead matrix remodeling. Intracellular mechanics alter transcription factors, impacting decision making. Additionally, from soluble factors substrate stiffness ligand density, modulate dynamics. Computational models closely integrated experimental support, incorporating cancer-specific parameters, provide quantitative assessments serve predictive tools toward dissecting feedback between across multiple scales domains tumor progression.