Passive immunotherapies targeting Aβ and tau in Alzheimer's disease.
作者： Steven S. Plotkin , Neil R. Cashman
DOI: 10.1016/J.NBD.2020.105010
关键词:
摘要: … This review will focus on therapies targeting Aβ and tau in clinical trials, … , Aβ and tau have been shown to have intimately connected pathology, and therapeutic strategies targeting Aβ …
sci-hub.st 参考文章(316)
A. K. Paravastu, R. D. Leapman, W.-M. Yau, R. Tycko, Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 18349- 18354 ,(2008) , 10.1073/PNAS.0806270105
Todd Golde, Pritam Das, Yona Levites, Quantitative and Mechanistic Studies of Aβ Immunotherapy Cns & Neurological Disorders-drug Targets. ,vol. 8, pp. 31- 49 ,(2009) , 10.2174/187152709787601830
Reeteka Sud, Evan T Geller, Gerard D Schellenberg, Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies Molecular therapy. Nucleic acids. ,vol. 3, ,(2014) , 10.1038/MTNA.2014.30
John Hardy, A Hundred Years of Alzheimer's Disease Research Neuron. ,vol. 52, pp. 3- 13 ,(2006) , 10.1016/J.NEURON.2006.09.016
David Miles, Gunter von Minckwitz, Andrew D. Seidman, Combination Versus Sequential Single-Agent Therapy in Metastatic Breast Cancer Oncologist. ,vol. 7, pp. 13- 19 ,(2002) , 10.1634/THEONCOLOGIST.8-1-124
O. Adolfsson, M. Pihlgren, N. Toni, Y. Varisco, A. L. Buccarello, K. Antoniello, S. Lohmann, K. Piorkowska, V. Gafner, J. K. Atwal, J. Maloney, M. Chen, A. Gogineni, R. M. Weimer, D. L. Mortensen, M. Friesenhahn, C. Ho, R. Paul, A. Pfeifer, A. Muhs, R. J. Watts, An Effector-Reduced Anti-β-Amyloid (Aβ) Antibody with Unique Aβ Binding Properties Promotes Neuroprotection and Glial Engulfment of Aβ The Journal of Neuroscience. ,vol. 32, pp. 9677- 9689 ,(2012) , 10.1523/JNEUROSCI.4742-11.2012
Bengt Winblad, Ana Graf, Marie-Emmanuelle Riviere, Niels Andreasen, J Ryan, Active immunotherapy options for Alzheimer's disease. Alzheimer's Research & Therapy. ,vol. 6, pp. 7- 7 ,(2014) , 10.1186/ALZRT237
Clifford R Jack, David S Knopman, William J Jagust, Leslie M Shaw, Paul S Aisen, Michael W Weiner, Ronald C Petersen, John Q Trojanowski, Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade Lancet Neurology. ,vol. 9, pp. 119- 128 ,(2010) , 10.1016/S1474-4422(09)70299-6
Garegin A. Papoian, Peter G. Wolynes, The physics and bioinformatics of binding and folding-an energy landscape perspective. Biopolymers. ,vol. 68, pp. 333- 349 ,(2003) , 10.1002/BIP.10286
Manjula P. Reddy, Cheryl Ann S. Kinney, Margery A. Chaikin, Angela Payne, Jacqueline Fishman-Lobell, Ping Tsui, Paul R. Dal Monte, Michael L. Doyle, Michael R. Brigham-Burke, Darrell Anderson, Mitchell Reff, Roland Newman, Nabil Hanna, Raymond W. Sweet, Alemseged Truneh, Elimination of Fc Receptor-Dependent Effector Functions of a Modified IgG4 Monoclonal Antibody to Human CD4 The Journal of Immunology. ,vol. 164, pp. 1925- 1933 ,(2000) , 10.4049/JIMMUNOL.164.4.1925