Alzheimer's disease: Recent treatment strategies.

摘要: Alzheimer Disease (AD) is a neurodegenerative disease characterized by two neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular neurofibrillary tangles. Current treatment for AD (donepezil, galantamine, rivastigmine memantine) only symptomatic has modest benefits. Thus, the development drugs with potential to change progression been priority. Therapies targeting β have focus almost 30 years. However, highly promising recently failed show clinical benefits in phase III trials. Even positive findings presented Biogen on Aducanumab are not entirely clear further data necessary confirm its validity. Therefore, researchers turning their efforts around tau-targeting therapies, since tau protein appears be better correlated severity cognitive decline than β. Currently, most anti-tau agents trials immunotherapies they early stages research. Four monoclonal antibodies (Gosuranemab, Tilavonemab, Semorinemab Zagotenemab) one vaccine (AADvac1) reached II, so far. In this review, we discuss disease-modifying tested update information that still under evaluation.