Mapping of the neonatal Fc receptor in the rodent eye.

摘要: The neonatal Fc receptor (FcRn, FcRp, or Fcgrt) is a heterodimer composed of major histocompatibility complex (MHC)-I, which binds to both albumin and the portion immunoglobulin G (IgG).1,2 Unlike other Fcγ receptors that bind lower hinge region top Cγ2 domain, FcRn interface between Cγ3 IgG.2,3 binding site fragment contains several histidine residues account for pH-dependent interaction.2 This enables transport IgG(s) into blood by transcytosis, allowing intact IgG molecules pass through cells systemic circulation. also aids in increasing circulating half life temporary sequestration vessel endothelium protection from catabolism elimination. Several studies have detailed this transcytosis pathway. First, pinocytosed nonspecifically cell trafficked acidic endosome, where (in low-pH environment) it with high affinity. then diverts degradative lysosomal fate transports back surface, (at neutral pH) releases extracellular space.1 The was first identified rodents as transfers maternal IgGs mother young via intestine.4 mammary gland placental express mediates transfer protective immunoglobulins newborn.5,6 In addition, important note expressed brain microvasculature choroid plexus epithelium.7 Transcytosis has been shown use located on vascular endothelium.8,9 are mammalian adult endothelial cells, hepatocytes, histiocytes, monocytes, intestinal macrophages, dendritic bronchial epithelial kidney adipose tissue.5,10-14 However, distribution eye not yet determined. Accordingly, purpose study determine whether expression occurs various ocular tissues.