Adaptive Immune System and the Eye: Mucosal Immunity

摘要: The mucosal immune system prevents microbes from infecting the body’s moist interfaces with external environment while avoiding inflammatory responses. It employs secretory immunoglobulin A (sIgA) and IgG1, induced in stereotypically organized mucosal-associated lymphoid tissues gastrointestinal, respiratory, renal systems, female male reproductive ocular surface system. Epithelial cells lacrimal glands, conjunctiva, drainage employ a specialized transcytotic apparatus to secrete immunoglobulins, but they also must maintain their underlying stromal spaces as niches for IgA+ plasmablast maturation plasmacyte survival. transforming growth factor-β functions importantly both inductive effector sites.