The immune geography of IgA induction and function
作者： A J Macpherson , K D McCoy , F-E Johansen , P Brandtzaeg
DOI: 10.1038/MI.2007.6
关键词:
摘要: The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is mostly exported across mucous membranes. discovery IgA the realization that dominates humoral mucosal immunity, contrast to IgG dominance systemic immune system, was early evidence for distinct nature immunology. It now clear can function high-affinity modes neutralization toxins pathogenic microbes, as a low-affinity system contain dense commensal microbiota within intestinal lumen. basic map induction B cells Peyer's patches, which then circulate through lymph bloodstream seed mucosa with precursors plasma produce dimeric export epithelium, has been known more than 30 years. In this review, we discuss mechanisms underlying selective geography their homing characteristics. We also review functionality secretory directed against both organisms pathogens.
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