Systematic variations in immune response-related gene transcript abundance suggest new questions about environmental influences on lacrimal gland immunoregulation.
作者： A. K. Mircheff , Y. Wang , P. B. Thomas , T. Nakamura , D. Samant
DOI: 10.3109/02713683.2010.550408
关键词:
摘要: Purpose: Retrospective analyses were undertaken to assess the hypothesis that environmental variables influenced immunophysiological status of lacrimal glands from untreated female rabbits had been housed out-of-doors until they acquired for use as controls experimental studies.Materials and Methods: Rabbits euthanized within 5 days arrival at University Vivaria. Glands divided histology RNA extraction. Transcript abundances determined with real time RT-PCR. Sections stained CD18 rabbit thymic lymphocyte antigen. Environmental assessed mean daily high temperature, low humidity, temperature/low humidity ratio, above average temperature/humidity ratio (“adverse days”) during prior 30 days.Results: Spearman’s revealed numerous significant correlations. Numbers T cells mRNAs CD8; CCL2, CCL4; IL-1α IL-1β; TH1 cytokine, IL-2; TH2- B cell cytokines, IL-4, IL-6, IL-1...
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