Humoral response to recombinant hepatitis B virus vaccine at birth: role of HLA and beyond.
作者： Miryam Martinetti , Annalisa De Silvestri , Cesare Belloni , Annamaria Pasi , Carmine Tinelli
关键词:
摘要: From 1991 to 1998 we vaccinated 4835 neonates against hepatitis B virus (HBV) and monitored their humoral response the recombinant vaccine. In a sample of 184 these babies studied association between HLA class I II genomic polymorphisms vaccine immune-mediated diseases. A subgroup 96 also underwent III (C4A C4B) typing. Four levels were identified, each with peculiar MHC restriction. Different products seem act as agonists (C4AQ0 HLA-DQB1(*)02) or antagonists (C4AQ0, HLA-DQB1(*)02, HLA-DRB1(*)11, DQB1(*)0301) in lowering HBV The group responders was characterized more for lacking "nonresponder" alleles than having specific "responder" ones. Tolerance peptides may have clinical implications, possibly being marker genetic risk immunopathologies. fact, many poor carried from two four HLA-DQ alpha beta heterodimers predisposing insulin-dependent diabetes mellitus celiac disease. Two true nonresponders suffered allergies slow had transient episodes hyperglycemia.
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sci-hub.se 参考文章(31)
G Kelsoe, J Xia, S Han, R G Howard, M Ma, M C Carroll, M B Fischer, S Goerg, E Kremmer, T L Rothstein, O Finco, F S Rosen, X Zhou, Regulation of the B cell response to T-dependent antigens by classical pathway complement. Journal of Immunology. ,vol. 157, pp. 549- 556 ,(1996)
A WINTER, E FOLLETT, J MCINTYRE, J STEWART, I SYMINGTON, Influence of smoking on immunological responses to hepatitis B vaccine. Vaccine. ,vol. 12, pp. 771- 772 ,(1994) , 10.1016/0264-410X(94)90283-6
G Barba, C Rittner, P M Schneider, Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression. Journal of Clinical Investigation. ,vol. 91, pp. 1681- 1686 ,(1993) , 10.1172/JCI116377
M. L. Clements, E. Miskovsky, M. Davidson, T. Cupps, N. Kumwenda, L. A. Sandman, D. West, T. Hesley, V. Ioll, W. Miller, G. Calandra, S. Krugman, Effect Of Age On The Immunogenicity Of Yeast Recombinant Hepatitis B Vaccines Containing Surface Antigen (S) Or Pres2+S Antigens The Journal of Infectious Diseases. ,vol. 170, pp. 510- 516 ,(1994) , 10.1093/INFDIS/170.3.510
Erik Thorsby, Invited anniversary review: HLA associated diseases Human Immunology. ,vol. 53, pp. 1- 11 ,(1997) , 10.1016/S0198-8859(97)00024-4
Mariapia A. Degli-Esposti, Anne L. Leaver, Frank T. Christiansen, Campbell S. Witt, Lawrence J. Abraham, Roger L. Dawkins, Ancestral haplotypes: conserved population MHC haplotypes. Human Immunology. ,vol. 34, pp. 242- 252 ,(1992) , 10.1016/0198-8859(92)90023-G
Rachel C. Wood, Risk Factors for Lack of Detectable Antibody Following Hepatitis B Vaccination of Minnesota Health Care Workers JAMA: The Journal of the American Medical Association. ,vol. 270, pp. 2935- 2939 ,(1993) , 10.1001/JAMA.1993.03510240047030
Susan L Prescott, Peter D Sly, Patrick G Holt, Raised serum IgE associated with reduced responsiveness to DPT vaccination during infancy The Lancet. ,vol. 351, pp. 1489- 1489 ,(1998) , 10.1016/S0140-6736(05)78871-1
L M Sollid, G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby, Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer. Journal of Experimental Medicine. ,vol. 169, pp. 345- 350 ,(1989) , 10.1084/JEM.169.1.345
A. B. McDermott, J. N. Zuckerman, C. A. Sabin, S. G. E. Marsh, J. A. Madrigal, Contribution of human leukocyte antigens to the antibody response to hepatitis B vaccination Tissue Antigens. ,vol. 50, pp. 8- 14 ,(1997) , 10.1111/J.1399-0039.1997.TB02827.X