Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.
作者： S S Kang , E L Passen , N Ruggie , P W Wong , H Sora
关键词:
摘要: BACKGROUNDTo determine whether or not a moderate genetic defect of homocysteine metabolism is associated with the development coronary artery disease, we studied prevalence thermolabile methylenetetrahydrofolate reductase, which probably most common metabolism.METHODS AND RESULTSThree hundred thirty-nine subjects who underwent angiography were classified into three groups: (1) patients severe stenosis (> = 70% occlusion in one more arteries > 50% left main artery), (2) mild to (< < and (3) non-coronary heart disease noncardiac chest pain (nonstenotic arteries). The thermolability reductase was prospectively determined all subjects. Plasma homocyst(e)ine levels then measured ...
sci-hub.se 参考文章(37)
James J. McGill, Gabrielle Mettler, David S. Rosenblatt, Charles R. Scriver, Detection of heterozygotes for recessive alleles. Homocyst(e)inemia: paradigm of pitfalls in phenotypes. American Journal of Medical Genetics. ,vol. 36, pp. 45- 52 ,(1990) , 10.1002/AJMG.1320360111
DeWitt S Goodman, Stephen B Hulley, Luther T Clark, CE Davis, Valentin Fuster, John C LaRosa, Albert Oberman, Ernst J Schaefer, Daniel Steinberg, W Virgil Brown, Scott M Grundy, Diane Becker, Edwin Bierman, Jacqueline Sooter-Bochenek, Rebecca Mullis, Neil Stone, Donald B Hunninghake, Jacqueline M Dunbar, Henry N Ginsberg, D Roger Illingworth, Harold C Sadin, Gustav Schonfeld, James I Cleeman, H Bryan Brewer, Nancy Ernst, William Friedewald, Jeffrey M Hoeg, Basil Rifkind, David Gordon, Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Archives of Internal Medicine. ,vol. 148, pp. 36- 69 ,(1988) , 10.1001/ARCHINTE.1988.00380010040006
D E Wilcken, B Wilcken, The pathogenesis of coronary artery disease. A possible role for methionine metabolism. Journal of Clinical Investigation. ,vol. 57, pp. 1079- 1082 ,(1976) , 10.1172/JCI108350
S S Kang, P W K Wong, M R Malinow, Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease Annual Review of Nutrition. ,vol. 12, pp. 279- 298 ,(1992) , 10.1146/ANNUREV.NU.12.070192.001431
Soo-Sang Kang, Paul W. K. Wong, Anil Bidani, Sylvia Milanez, Plasma protein-bound homocyst(e)ine in patients requiring chronic haemodialysis. Clinical Science. ,vol. 65, pp. 335- 336 ,(1983) , 10.1042/CS0650335
Godfried H.J. Boers, Antony G.H. Smals, Frans J.M. Trijbels, Brian Fowler, Jan A.J.M. Bakkeren, Henny C. Schoonderwaldt, Wim J. Kleijer, Peter W.C. Kloppenborg, Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease The New England Journal of Medicine. ,vol. 313, pp. 709- 715 ,(1985) , 10.1056/NEJM198509193131201
Robert Clarke, Leslie Daly, Killian Robinson, Eileen Naughten, Seamus Cahalane, Brian Fowler, Ian Graham, Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease New England Journal of Medicine. ,vol. 324, pp. 1149- 1155 ,(1991) , 10.1056/NEJM199104253241701
P M Ueland, H Refsum, Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy. Journal of Laboratory and Clinical Medicine. ,vol. 114, pp. 473- 501 ,(1989)
G Strokosch, J Zhou, P W Wong, S S Kang, J Kowalisyn, Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. American Journal of Human Genetics. ,vol. 43, pp. 414- 421 ,(1988)
M. Norusis, J. Sora, N. Ruggie, Soo-Sang Kang, P. W. K. Wong, A. Susmano, Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. American Journal of Human Genetics. ,vol. 48, pp. 536- 545 ,(1991)