Does the polymorphism 677C-T of the 5,10-methylenetetrahydrofolate reductase gene contribute to homocysteine-related vascular disease?
作者： L. Thuillier , B. Chadefaux-Vekemans , J. P. Bonnefont , A. Kara , J. Aupetit
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摘要: Whether the 677C-T polymorphism of methylene tetrahydrofolate reductase (MTHFR) gene acts as a risk factor for homocysteine-related vascular disease remains matter debate. Testing nucleotide substitution and assay plasma homocysteine were carried out simultaneously in 69 controls 113 patients from Paris area. The variant frequency well homozygous genotype very similar patients. Conversely, levels substantially higher than controls. A slight interaction between MTHFR homocysteinaemia was observed patient group only, while negative correlation fasting folate found all individuals genotype, irrespective disease. These data suggest that is not major determinant but contributes to increased concentration conjunction with low levels.
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