Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

摘要: // Yuan Qin 1, 2, * , Dong Zhao Hong-gang Zhou Xing-hui Wang 3, Wei-long Zhong 2 Shuang Chen Wen-guang Gu Wei Chun-hong Zhang Yan-rong Liu Hui-juan Qiang Yuan-qiang Guo Tao Sun Cheng Yang 1 State Key Laboratory of Medicinal Chemical Biology and College Pharmacy, Nankai University, Tianjin, China Tianjin Molecular Drug Research, University International Joint Academy Biomedicine, 3 Department Pathology, The People’s Hospital Shouguang City, Shouguang, Shandong Province, These authors contributed equally to this work Correspondence to: Yang, email: Cheng.yang@nankai.edu.cn Sun, sunrockmia@hotmail.com Keywords: apigenin, antitumor, EMT, metastasis, HCC Received: January 21, 2016      Accepted: April 11, Published: May 17, 2016 ABSTRACT Apigenin is a naturally occurring compound with anti-inflammatory, antioxidant, anticancer properties. In study, we investigated the effects apigenin on migration metastasis in experimental human hepatocellular carcinoma (HCC) cell lines vitro vivo . dose-dependently inhibited proliferation, migration, invasion by PLC Bel-7402 cells. It also suppressed tumor growth xenografts without altering body weight, thereby prolonging survival. reduced Snai1 NF-κB expression, reversed increases epithelial-mesenchymal transition (EMT) marker levels, increased cellular adhesion, regulated actin polymerization may therefore inhibit EMT inhibiting NF-κB/Snail pathway HCC.